Antazoline Hydrochloride

Names

[ Name ]:
Antazoline Hydrochloride

[Synonym ]:
Antazoline Hydrochloride
hydrochloride salt of antazoline
Antazoline HCl
UNII-FP8Q8F72JH
Fenazolina
Antistine hydrochloride
Histazine
2-(N-Benzylanilinomethyl)-2-imidazoline Hydrochloride
N-Benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline hydrochloride (1:1)
Antazolinium chloratum
N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-aniline,hydrochloride
MFCD00058145
1H-Imidazole-2-methanamine, 4,5-dihydro-N-phenyl-N-(phenylmethyl)-, hydrochloride (1:1)
EINECS 219-719-8
Phenazoline hydrochloride
N-Benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-anilin,Hydrochlorid
Antazoline (hydrochloride)

Biological Activity

[Description]:

Antazoline hydrochloride is a 1st generation antihistamine with also anticholinergic properties used to relieve nasal congestion and in eye drops.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor

Research Areas >> Neurological Disease

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
475.5ºC at 760 mmHg

[ Melting Point ]:
238 °C

[ Molecular Formula ]:
C₁₇H₂₀ClN₃

[ Molecular Weight ]:
301.814

[ Flash Point ]:
241.4ºC

[ Exact Mass ]:
301.134583

[ PSA ]:
27.63000

[ LogP ]:
3.26130

[ Vapour Pressure ]:
3.31E-09mmHg at 25°C

[ Storage condition ]:
Store at RT

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NJ2150000

CHEMICAL NAME :: 2-Imidazoline, 2-((N-benzylanilino)methyl)-, hydrochloride

CAS REGISTRY NUMBER :: 2508-72-7

LAST UPDATED :: 199012

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C17-H19-N3.Cl-H

MOLECULAR WEIGHT :: 301.85

WISWESSER LINE NOTATION :: T5M CN BUTJ B1NR&1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - irritability Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 10,338,1951

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 17100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 113,313,1958

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H315-H319-H332-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R20/21/22;R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
NJ2150000

[ HS Code ]:
2933290090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933290090

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Method development for impurity profiling in SFC: The selection of a dissimilar set of stationary phases.

J. Pharm. Biomed. Anal. 111 , 333-43, (2015)

Supercritical fluid chromatography (SFC) is drawing considerable interest as separation technique in the pharmaceutical industry. The technique is already well established in chiral separations both a...

Antinociceptive, anti-inflammatory and smooth muscle relaxant activities of the pyrrolo[3,4-d]pyridazinone derivatives: Possible mechanisms of action.

Pharmacol. Biochem. Behav. 133 , 99-110, (2015)

The aim of this study was to evaluate the analgesic as well as anti-inflammatory activities of the new pyrrolo[3,4-d]pyridazinone derivatives. Moreover, the present study attempted to assess some of t...

Treatment of allergic conjunctivitis: results of a 1-month, single-masked randomized study.

Eur. J. Ophthalmol. 20(5) , 811-8, (2010)

To compare the effects of topical antiallergic eyedrops in relieving the signs and symptoms of patients with allergic conjunctival pathology.In this multicenter, single-masked, randomized study, 240 p...

Related Compounds

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