hCAXII-IN-2

Names

[ CAS No. ]:
2497504-86-4

[ Name ]:
hCAXII-IN-2

Biological Activity

[Description]:

hCAXII-IN-2 (compound 5i) is a potent human carbonic anhydrase XII (hCA XII) and hCA IX inhibitor with Ki values of 84.2 nM and 268.5 nM, respectively. hCAXII-IN-2 shows less active against hCA I and hCA II[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase

[Target]

Ki: 84.2 nM (hCA XII) and 268.5 nM (hCA IX)[1]


[References]

[1]. Pavitra S Thacker, et al. Synthesis and biological evaluation of some coumarin hybrids as selective carbonic anhydrase IX and XII inhibitors. Bioorg Chem. 2020 Nov;104:104272.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H18ClN3O4

[ Molecular Weight ]:
411.84

Related Compounds