2497504-86-4

2497504-86-4 structure

Name: hCAXII-IN-2
Chemical Name: hCAXII-IN-2
CAS Number: 2497504-86-4
Molecular Formula: C₂₁H₁₈ClN₃O₄
Molecular Weight: 411.84
Catalog: Signaling Pathways Metabolic Enzyme/Protease Carbonic Anhydrase
Create Date: 2022-08-17 14:34:20
Modify Date: 2024-01-12 16:58:51
hCAXII-IN-2 (compound 5i) is a potent human carbonic anhydrase XII (hCA XII) and hCA IX inhibitor with Ki values of 84.2 nM and 268.5 nM, respectively. hCAXII-IN-2 shows less active against hCA I and hCA II[1].

Name	hCAXII-IN-2

Description	hCAXII-IN-2 (compound 5i) is a potent human carbonic anhydrase XII (hCA XII) and hCA IX inhibitor with Ki values of 84.2 nM and 268.5 nM, respectively. hCAXII-IN-2 shows less active against hCA I and hCA II[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase
Target	Ki: 84.2 nM (hCA XII) and 268.5 nM (hCA IX)[1]
References	[1]. Pavitra S Thacker, et al. Synthesis and biological evaluation of some coumarin hybrids as selective carbonic anhydrase IX and XII inhibitors. Bioorg Chem. 2020 Nov;104:104272.

Molecular Formula	C₂₁H₁₈ClN₃O₄
Molecular Weight	411.84