hCAIX-IN-10

hCAIX-IN-10 (Compound 6i) is a selective carbonic anhydrase IX and XII inhibitor with Ki s of 61.5 and 586.8 nM for hCA IX and hCA XII, respectively.  hCA IX and hCA XII are transmembrane isoforms which have been characterized as biomarkers for several types of tumors. The hCA XII assists in maintenance of acid-base homoeostasis in normal as well as tumor cells[1].

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase

Ki: 61.5 nM (hCA IX), 586.8 nM (hCA XII)[1]

hCAIX-IN-10 (compound 6i) is a strong inhibitor of hCA IX rather than hCA XII in vitro[1]. hCAIX-IN-10 (0.1 nM-0.1 mM; 6 h) inhibits carbonic anhydrases enzyme activity[1].

[1]. Pavitra S Thacker,et al. Synthesis and biological evaluation of some coumarin hybrids as selective carbonic anhydrase IX and XII inhibitors. Bioorg Chem. 2020 Nov;104:104272.