hCAIX-IN-8

hCAIX-IN-8 (compound 7i) is a potent and selective hCAIX inhibitor with IC50s of 1.99, 0.024, 1.10 µM for CAII, CAIX, CAVA respectively. hCAIX-IN-8 shows anti-proliferation activity with low toxicity. hCAIX-IN-8 decreases the epithelial to mesenchymal transitions and induces apoptosis. hCAIX-IN-8 inhibits cell migration and colonization potential[1].

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase

IC50: 1.99 µM (CAII); 0.024 (CAIX), 1.10 µM (CAVA)[1]

hCAIX-IN-8 (compound 7i) shows anti-proliferation activity with IC50是of 8.44, 11.22 µM for HT29, HepG2 cells, respectively[1]. hCAIX-IN-8 induces apoptosis in 24.44% and 19.22% of HT29 and HepG2 cells, respectivelysup>[1].

[1]. Aneja B,et al. Design, synthesis & biological evaluation of ferulic acid-based small molecule inhibitors against tumor-associated carbonic anhydrase IX. Bioorg Med Chem. 2020 May 1;28(9):115424.