FGFR-IN-7

Names

[ Name ]:
FGFR-IN-7

Biological Activity

[Description]:

FGFR-IN-7 (compound 17) is an orally active, potent and BBB-penetrated FGFR (fibroblast growth factor receptor) modulator. FGFR-IN-7 shows neuroprotective activity. FGFR-IN-7 improves brain exposure and reduced risk of phospholidosis. FGFR-IN-7 can be used for neurodegenerative diseases research[1].

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR

Research Areas >> Neurological Disease

[In Vivo]

FGFR-IN-7 (compound 17) (1 mg/kg, Orally, once daily for 10 days) significantly enhances recovery of coordinated movement in the in vivo rat acute stroke model[1].

[References]

[1]. Sakai H, et al. Fibroblast growth factor receptor modulators employing diamines with reduced phospholipidosis-inducing potential. Bioorg Med Chem. 2020 Jul 15;28(14):115562.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₂₁ClF₂N₄O₂

[ Molecular Weight ]:
374.81

Related Compounds

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