Pom-8PEG

Names

[ Name ]:
Pom-8PEG

Biological Activity

[Description]:

Pom-8PEG, an E3 ligase ligand-linker conjugate, incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase and an 8-unit PEG linker. Pom-8PEG can be used in the synthesis of PROTAC, such as IDO1 PROTAC degrader[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

[Target]

Cereblon

[References]

[1]. Hu M, et al. Discovery of the first potent proteolysis targeting chimera (PROTAC) degrader of indoleamine 2,3-dioxygenase 1. Acta Pharm Sin B. 2020;10(10):1943-1953.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₄₃N₃O₁₂

[ Molecular Weight ]:
625.66

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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