POM 1

Names

[ Name ]:
POM 1

[Synonym ]:
SODIUM POLYTUNGSTATE
POM 1
4-Acetyl-1,1-dimethylpiperazinium iodide
Sodium metatungstate monohydrate
EINECS 412-770-9
Sodium metatungstate
SODIUM POLYTINGSTATE
hexasodium tungstate hydrate
Sodium polytungstate solution
TUNGSTATEHEXASODIUM
MFCD00061466

Biological Activity

[Description]:

POM1 is a potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitor, with Ki values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1, NTPDase 3 and NTPDase 2 respectively[1]. POM1 inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition[2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[Target]

Ki: 2.58 μM (NTPDase 1), 3.26 μM (NTPDase 3), 28.8 μM (NTPDase 2)[1].

[References]

[1]. Müller CE, et al. Polyoxometalates--a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors. Bioorg Med Chem Lett. 2006 Dec 1;16(23):5943-7.

[2]. Wall et al. The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition. Neuropharmacology. 2008 Dec;55(7):1251-8.

Chemical & Physical Properties

[ Density]:
3.1 g/cm3

[ Molecular Formula ]:
H₂Na₆O₄₀W₁₂

[ Molecular Weight ]:
2986.01

[ Exact Mass ]:
2969.15000

[ PSA ]:
701.67000

[ Index of Refraction ]:
n20/D 1.5555

[ Storage condition ]:
Store at RT

[ Water Solubility ]:
Soluble in water.

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H318-H412

[ Precautionary Statements ]:
P273-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
26-39-61

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

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Related Compounds

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