SIRT6 activator CL5D

Names

[ Name ]:
SIRT6 activator CL5D

Biological Activity

[Description]:

SIRT6 activator CL5D is a novel small-molecule activator of SIRT6 deacetylation, stimulates 4-fold activation of SIRT6 (1 uM) against H3K9ac (20 uM) at 3 uM.CL5D demonstrate competitive inhibition with Ki of 13.4 uM.CL5D exhibited time-dependent deacetylation at H3K9 by SIRT6 in HEK293T cells.

[References]

1. Mark A Klein, et al. J Biol Chem. 2020 Jan 31;295(5):1385-1399.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₁₁Cl₇N₂O₆

[ Molecular Weight ]:
731.565

Related Compounds

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