Furanone C-30

Names

[ Name ]:
Furanone C-30

[Synonym ]:
Furanone C-30
(5Z)-4-Bromo-5-(bromomethylene)-2(5H)-furanone
(5Z)-4-Bromo-5-(bromomethylene)-2(5H)-furanone

Biological Activity

[Description]:

Furanone C-30 is a synthetic furanone bacterial quorum sensing inhibitor. Furanone C-30 inhibits virulence factor expression in Pseudomonas aeruginosa and increases bacterial susceptibility to antibiotics in vitro.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial

Chemical & Physical Properties

[ Density]:
2.650±0.06 g/cm3

[ Boiling Point ]:
205.9±40.0 ºC (760 Torr)

[ Melting Point ]:
97-99 ºC

[ Molecular Formula ]:
C₅H₂Br₂O₂

[ Molecular Weight ]:
253.87600

[ Flash Point ]:
78.3±27.3 ºC

[ Exact Mass ]:
251.84200

[ PSA ]:
26.30000

[ LogP ]:
2.05830

[ Storage condition ]:
20°C

[ Water Solubility ]:
Slightly soluble (6.3 g/L) (25 ºC)

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2932209090

Customs

[ HS Code ]: 2932209090

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Synthetic furanones inhibit quorum-sensing and enhance bacterial clearance in Pseudomonas aeruginosa lung infection in mice.

J. Antimicrob. Chemother. 53(6) , 1054-1061, (2004)

Antibiotics are used to treat bacterial infections by killing the bacteria or inhibiting their growth, but resistance to antibiotics can develop readily. The discovery that bacterial quorum-sensing re...

The use of (5Z)-4-bromo-5-(bromomethylene)-2(5H)-furanone for controlling acid mine drainage through the inhibition of Acidithiobacillus ferrooxidans biofilm formation.

Bioresour. Technol. 186 , 52-7, (2015)

The aim of this study was to determine whether acid mine drainage (AMD) production can be decreased by (5Z)-4-bromo-5-(bromomethylene)-2(5H)-furanone (furanone C-30) in the presence of Acidithiobacill...