Dihydro-5-azacytidine acetate

Names

[ CAS No. ]:
2470972-18-8

[ Name ]:
Dihydro-5-azacytidine acetate

Biological Activity

[Description]:

Dihydro-5-azacytidine acetate (DHAC), the nucleoside analog, is incorporated into DNA and inhibits DNA methylation. Dihydro-5-azacytidine acetate has an antitumor activity[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
Signaling Pathways >> Epigenetics >> DNA Methyltransferase

[References]

[1]. Robert A Kratzke, et al. Response to the methylation inhibitor dihydro-5-azacytidine in mesothelioma is not associated with methylation of p16INK4a: results of cancer and leukemia group B 159904. J Thorac Oncol. 2008 Apr;3(4):417-21.  

[2]. W C Powell, et al. Biochemical pharmacology of 5,6-dihydro-5-azacytidine (DHAC) and DNA hypomethylation in tumor (L1210)-bearing mice. Cancer Chemother Pharmacol. 1988;21(2):117-21.  

Chemical & Physical Properties

[ Molecular Formula ]:
C10H18N4O7

[ Molecular Weight ]:
306.27

Related Compounds

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