YS-363

Names

[ Name ]:
YS-363

Biological Activity

[Description]:

YS-363 is a potent, selective, and orally active EGFR inhibitor, with IC50s of 0.96 nM and 0.67 nM for wild-type and L858R mutant forms of EGFR, respectively. YS-363 can induce G0/G1 cell cycle arrest and apoptosis[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> EGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[Target]

EGFR:0.96 nM (IC50)

[References]

[1]. He P, et, al. Discovery of YS-363 as a highly potent, selective, and orally eﬃcacious EGFR inhibitor. Biomed Pharmacother. 2023 Nov:167:115491.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₀H₃₀N₄O₃

[ Molecular Weight ]:
494.58

Related Compounds

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