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2470908-90-6

2470908-90-6 structure

2470908-90-6 structure

Name: YS-363
Chemical Name: YS-363
CAS Number: 2470908-90-6
Molecular Formula: C₃₀H₃₀N₄O₃
Molecular Weight: 494.58
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2024-03-10 18:11:44
Modify Date: 2025-08-25 13:28:56
YS-363 is a potent, selective, and orally active EGFR inhibitor, with IC50s of 0.96 nM and 0.67 nM for wild-type and L858R mutant forms of EGFR, respectively. YS-363 can induce G0/G1 cell cycle arrest and apoptosis[1].

Name	YS-363

Description	YS-363 is a potent, selective, and orally active EGFR inhibitor, with IC50s of 0.96 nM and 0.67 nM for wild-type and L858R mutant forms of EGFR, respectively. YS-363 can induce G0/G1 cell cycle arrest and apoptosis[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	EGFR:0.96 nM (IC50)
References	[1]. He P, et, al. Discovery of YS-363 as a highly potent, selective, and orally eﬃcacious EGFR inhibitor. Biomed Pharmacother. 2023 Nov:167:115491.

Molecular Formula	C₃₀H₃₀N₄O₃
Molecular Weight	494.58

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