CSNK1-IN-2

Names

[ CAS No. ]:
2468783-76-6

[ Name ]:
CSNK1-IN-2

Biological Activity

[Description]:

CSNK1-IN-2 is a CSNK1A1 inhibitor. CSNK1-IN-1 has inhibitory activity for CSNK1A1 kinase with IC50 values of 2.52 μM. CSNK1-IN-2 can be used for the research of proliferative disorders[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[Target]

IC50: 2.52 μM (CSNK1A1 kinase)[1]


[In Vitro]

CSNK1-IN-2 (example 7) 对 CSNK1A1、CSNK1D 和 CSNK1A1 (高 ATP) 具有抑制活性，IC50 值分别为 2.52 μM、8.48 μM 和 107 μM[1]。< br / >CSNK1-IN-2 对野生型 EGFR 激酶具有抑制作用，其 IC50 值为 2.74 nM[1]。

[References]

[1]. Volker Schulze, et al. 3-amino-2-[2-(acylamino)pyridin-4-yl]-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-c]pyridin-4-one as csnk1 inhibitors. Patent. WO2020161257 A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C28H26FN5O2

[ Molecular Weight ]:
483.54

Related Compounds

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