Influenza A virus-IN-7

Names

[ CAS No. ]:
2464415-40-3

[ Name ]:
Influenza A virus-IN-7

Biological Activity

[Description]:

Influenza A virus-IN-7 (compound 16r) is a potent and orally active influenza A virus inhibitor with an IC50 of 3.43 µM and CC50 of >100 µM. Influenza A virus-IN-7 shows anti-IAV activity with low cytotoxicity. Influenza A virus-IN-7 inhibits the transcription and replication of viral RNA[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Influenza Virus
Research Areas >> Inflammation/Immunology

[Target]

IC50: 3.43 µM (influenza virus); CC50: >100 µM (influenza virus)[1]


[In Vivo]

Influenza A virus-IN-7 (compound 16r) (1.25 mg/kg for i.v.; 25 mg/kg for p.o.) shows good PK profiles with oral bioavailability of 22.5%[1]. Animal Model: Male SD rats[1] Dosage: 1.25, 25 mg/kg Administration: I.v. or p.o Result: Showed good PK profiles with oral bioavailability of 22.5%.

[References]

[1]. Zhang G, et al. Design, synthesis and in vitro anti-influenza A virus evaluation of novel quinazoline derivatives containing S-acetamide and NH-acetamide moieties at C-4. Eur J Med Chem. 2020 Nov 15;206:112706.

Chemical & Physical Properties

[ Molecular Formula ]:
C29H25N5O

[ Molecular Weight ]:
459.54

Related Compounds