HDAC-IN-40

HDAC-IN-40 is a potent alkoxyamide-based HDAC inhibitor with Ki values of 60 nM and 30 nM for HDAC2 and HDAC6, respectively. HDAC-IN-40 had antitumor effects[1].

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC

Signaling Pathways >> Epigenetics >> HDAC

HDAC2:60 nM (Ki)

HDAC6:30 nM (Ki)

HDAC4:49200 μM (Ki)

HDAC8:5690 nM (Ki)

HDAC-IN-40 (Compound 13d) shows antiproliferative activity against the cell line A2780 and Cal27 with IC50 values of 0.89 µM and 0.72 µM, respectively[1]. HDAC-IN-40 induces accumulation of acetyl α-tubulin in Cal27 and Cal27CisR[1]. HDAC-IN-40 enhances the Cisplatin-induced cytotoxicity via caspase-3/7 activation[1].

[1]. Yodita Asfaha, et al. Novel alkoxyamide-based histone deacetylase inhibitors reverse cisplatin resistance in chemoresistant cancer cells. Bioorg Med Chem. 2020 Jan 1;28(1):115108.