AL 8810

Names

[ Name ]:
AL 8810

[Synonym ]:
al 8810
(5Z)-7-{(1R,2R,3S,5S)-2-[(1E,3R)-3-(2,3-Dihydro-1H-inden-2-yl)-3-hydroxyprop-1-en-1-yl]-3-fluoro-5-hydroxycyclopentyl}hept-5-enoic acid
5-Heptenoic acid, 7-[(1R,2R,3S,5S)-2-[(1E,3R)-3-(2,3-dihydro-1H-inden-2-yl)-3-hydroxy-1-propen-1-yl]-3-fluoro-5-hydroxycyclopentyl]-, (5Z)-
(5Z)-7-{(1R,2R,3S,5S)-2-[(1E,3R)-3-(2,3-Dihydro-1H-inden-2-yl)-3-hydroxy-1-propen-1-yl]-3-fluoro-5-hydroxycyclopentyl}-5-heptenoic acid

Biological Activity

[Description]:

AL-8810 is an 11β-fluoro analog of PGF2α and acts as a potent and selective antagonist of the PGF2αreceptor (FP receptor)[1].

[Related Catalog]:

Research Areas >> Endocrinology

Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor

[References]

[1]. Griffin BW, et al. AL-8810: a novel prostaglandin F2 alpha analog with selective antagonist effects at the prostaglandin F2 alpha (FP) receptor. J Pharmacol Exp Ther. 1999 Sep;290(3):1278-84.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
594.6±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₃₁FO₄

[ Molecular Weight ]:
402.499

[ Flash Point ]:
313.4±30.1 °C

[ Exact Mass ]:
402.220642

[ PSA ]:
77.76000

[ LogP ]:
4.00

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.584

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Arachidonic acid-dependent gene regulation during preadipocyte differentiation controls adipocyte potential.

J. Lipid Res. 55(12) , 2479-90, (2014)

Arachidonic acid (AA) is a major PUFA that has been implicated in the regulation of adipogenesis. We examined the effect of a short exposure to AA at different stages of 3T3-L1 adipocyte differentiati...

Role of contractile prostaglandins and Rho-kinase in growth factor-induced airway smooth muscle contraction.

Respir. Res. 6 , 85, (2005)

In addition to their proliferative and differentiating effects, several growth factors are capable of inducing a sustained airway smooth muscle (ASM) contraction. These contractile effects were previo...