Antibacterial agent 106

Names

[ Name ]:
Antibacterial agent 106

Biological Activity

[Description]:

Antibacterial agent 106 (compound 8) is an orally active and potent antibacterial agent with antibiofilm activity. Antibacterial agent 106 shows potent antibacterial effect against multi-drug resistant (MDR)-Gram positive pathogens. Antibacterial agent 106 is highly effective in clearing 99.7% of the intracellular methicillin-resistant S. aureus (MRSA) harbored inside macrophages[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vivo]

Antibacterial agent 106 (compound 8) can penetrate gut cells and reach plasma within 15 min and maintain effective plasma concentration for around 12 h[1].

[References]

[1]. Hosny Y, et al. Modifying the lipophilic part of phenylthiazole antibiotics to control their drug-likeness. Eur J Med Chem. 2020 Jan 1;185:111830.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₄N₆S

[ Molecular Weight ]:
380.51

Related Compounds

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