FNC-TP

Names

[ Name ]:
FNC-TP

Biological Activity

[Description]:

FNC-TP is the intracellular active form of FNC. FNC is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV

Signaling Pathways >> Anti-infection >> HCV

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> HBV

Signaling Pathways >> Anti-infection >> Reverse Transcriptase

[Target]

reverse transcriptase[1] HIV[1] HBV[1] HCV[1]

[In Vitro]

FNC (0.1-10 nM; 24-240 h) is found mainly to accumulate in these HIV-1 target cells, and the retention of FNC-TP is 2-4 times higher than in other types of cells[1].

[In Vivo]

FNC (1-6 mg/kg; a single p.o.) could enter rhesus macaque PBMCs and form the active nucleoside triphosphate FNC-TP[1].

[References]

[1]. Sun L, et, al. Mechanistic Insight into Antiretroviral Potency of 2'-Deoxy-2'-β-fluoro-4'-azidocytidine (FNC) with a Long-Lasting Effect on HIV-1 Prevention. J Med Chem. 2020 Aug 13;63(15):8554-8566.

Chemical & Physical Properties

[ Molecular Formula ]:
C₉H₁₄FN₆O₁₃P₃

[ Molecular Weight ]:
526.16

Related Compounds

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