MSU-42011

Names

[ Name ]:
MSU-42011

Biological Activity

[Description]:

MSU-42011 is an orally active retinoid X receptor (RXR) agonist. MSU-42011 inhibits the expression of iNOS and p-ERK protein. MSU-42011 has immunomodulatory and antitumor activity. MSU-42011 can be used for cancer research[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Immunology/Inflammation >> NO Synthase

Signaling Pathways >> Cell Cycle/DNA Damage >> PERK

Signaling Pathways >> Metabolic Enzyme/Protease >> RAR/RXR

[References]

[1]. Moerland JA, et al. The novel rexinoid MSU-42011 is effective for the treatment of preclinical Kras-driven lung cancer. Sci Rep. 2020 Dec 17;10(1):22244.

[2]. Leal AS, et al. The RXR Agonist MSU42011 Is Effective for the Treatment of Preclinical HER2+ Breast Cancer and Kras-Driven Lung Cancer. Cancers (Basel). 2021 Oct 6;13(19):5004.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₃₄N₂O₂

[ Molecular Weight ]:
382.54