2,6-Diisopropylaniline

Names

[ Name ]:
2,6-Diisopropylaniline

[Synonym ]:
2,5-DIHYDRO-5-OXO-1-(3-TRIFLUOROMETHYLPHENYL)-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID DIMETHYLAMIDE
2,6-Diisopropylaniline (DIPA)
Aniline,2,6-diisopropyl
EINECS 246-305-4
2,6-Dilsopropylaniline
2,6-bis(1-methylethyl)aniline
2,6-Diisopropyl-phenylamine
2,6-bis(1-methylethyl)benzenamine
2,6-DIISOPROPYLPHENYLAMINE
MFCD00008887
2,6-(i-Pr)2PhNH2
2,6-di(propan-2-yl)aniline
(2,6-iPr2C6H3)NH2
Benzenamine, 2,6-bis(1-methylethyl)-
2,6-Diisopropylaniline
Benzenamine,2,6-bis(1-methylethyl)
2,6-di-i-propylaniline

Biological Activity

[Description]:

2,6-Diisopropylaniline is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

2,6-Diisopropylaniline 用作生产碳化二亚胺稳定剂、合成树脂、抗氧化剂和药物活性成分的中间体。它还用于制备多主题席夫碱配体前体和 4,5-b is(2,6-diisopropylanilino)-2,7-di-tert-butyl-9,9-dimethylthioxanthene。与三乙酰甲烷缩合生成-[1-(2,6-二异丙基苯基氨基)乙烯]戊烷-2,4-二酮。此外，它还用于制备 N-杂环卡宾络合物，用于无环酮的 α-芳基化、卤代芳烃的胺化和水性铃木偶联。除此之外，它还用于制备基于萘二酰亚胺的有机催化剂。

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
257.3±9.0 °C at 760 mmHg

[ Melting Point ]:
−45 °C(lit.)

[ Molecular Formula ]:
C₁₂H₁₉N

[ Molecular Weight ]:
177.29

[ Flash Point ]:
123.9±0.0 °C

[ Exact Mass ]:
177.151749

[ PSA ]:
26.02000

[ LogP ]:
3.61

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.526

[ Water Solubility ]:
<0.20 g/L

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BX4025000

CHEMICAL NAME :: Aniline, 2,6-diisopropyl-

CAS REGISTRY NUMBER :: 24544-04-5

BEILSTEIN REFERENCE NO. :: 2208763

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C12-H19-N

MOLECULAR WEIGHT :: 177.32

WISWESSER LINE NOTATION :: 1Y1&R BZ CY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3204 mg/kg

TOXIC EFFECTS :: Liver - other changes Blood - changes in bone marrow (not otherwise specified) Blood - changes in spleen

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 3,285,1983 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4005 mg/kg/5D-C

TOXIC EFFECTS :: Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 3,285,1983

Safety Information

[ Hazard Statements ]:
H412

[ Precautionary Statements ]:
P273

[ Personal Protective Equipment ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S61-S37/39-S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
BX4025000

[ HS Code ]:
29214980

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2921420090

[ Summary ]:
HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Organo-palladium(II) complexes bearing unsymmetrical N,N,N-pincer ligands: synthesis, structures and oxidatively induced coupling reactions.

Dalton Trans. 44(16) , 7230-41, (2015)

The 2-(2′-aniline)-6-imine-pyridines, 2-(C6H4-2′-NH2)-6-(CMe=NAr)C5H3N (Ar = 4-i-PrC6H4 (HL1a), 2,6-i-Pr2C6H3 (HL1b)), have been synthesised via sequential Stille cross-coupling, deprotection and cond...

O,N,N-pincer ligand effects on oxidatively induced carbon-chlorine coupling reactions at palladium.

Dalton Trans. 44(13) , 6040-51, (2015)

The syntheses of two families of sterically tuneable O,N,N pro-ligands are reported, namely the 2-(phenyl-2'-ol)-6-imine-pyridines, 2-(C6H4-2'-OH),6-(CMe=NAr)C5H3N [Ar = 4-i-PrC6H4 (HL1(a)), 2,6-i-Pr2...

Rigid NON- and NSN-ligand complexes of tetravalent and trivalent uranium: comparison of U-OAr2 and U-SAr2 bonding.

Dalton Trans. 41(26) , 8175-89, (2012)

A rigid NSN-donor proligand, 4,5-bis(2,6-diisopropylanilino)-2,7-di-tert-butyl-9,9-dimethylthioxanthene (H(2)[TXA(2)], 1) was prepared by palladium-catalyzed coupling of 2,6-diisopropylaniline with 4,...