2-(6-METHOXY-3-OXO-2,3-DIHYDRO-1H-INDEN-1-YL)ACETIC ACID

Names

[ Name ]:
2-(6-METHOXY-3-OXO-2,3-DIHYDRO-1H-INDEN-1-YL)ACETIC ACID

[Synonym ]:
(6-Methoxy-3-oxo-indan-1-yl)-essigsaeure
1H-Indene-1-acetic acid,2,3-dihydro-6-methoxy-3-oxo
6-Methoxy-3-oxo-1-indanacetic acid
2-(6-methoxy-3-oxo-2,3-dihydro-1H-inden-1-yl)ethanoic acid
(6-methoxy-3-oxo-indan-1-yl)-acetic acid
MFCD00003787
6-Methoxy-3-oxo-2,3-dihydro-1H-indene-1-acetic acid
2-(6-methoxy-3-oxo-2,3-dihydro-1H-inden-1-yl)acetic acid
5-Methoxy-1-indanone-3-acetic acid

Chemical & Physical Properties

[ Density]:
1.286g/cm3

[ Boiling Point ]:
428.7ºC at 760mmHg

[ Melting Point ]:
139-144ºC(lit.)

[ Molecular Formula ]:
C₁₂H₁₂O₄

[ Molecular Weight ]:
220.22100

[ Flash Point ]:
170.6ºC

[ Exact Mass ]:
220.07400

[ PSA ]:
63.60000

[ LogP ]:
1.83990

[ Vapour Pressure ]:
4.11E-08mmHg at 25°C

[ Index of Refraction ]:
1.569

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NK8225760

CHEMICAL NAME :: 1H-Indene-1-acetic acid, 2,3-dihydro-6-methoxy-3-oxo-

CAS REGISTRY NUMBER :: 24467-92-3

BEILSTEIN REFERENCE NO. :: 2118149

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C12-H12-O4

MOLECULAR WEIGHT :: 220.24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IJPPAZ Indian Journal of Physiology and Pharmacology. (All India Institute of Medical Sciences, Dept. of Physiology, Ansari Nagar, New Delhi 110 029, India) V.1- 1957- Volume(issue)/page/year: 24,310,1980

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
NK8225760

[ HS Code ]:
2918990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Selective inhibition of the chymotrypsin-like activity of the 20S proteasome by 5-methoxy-1-indanone dipeptide benzamides.

Bioorg. Med. Chem. Lett. 8(3) , 209-14, (1998)

Potent inhibitors of the 20S proteasome that contain a novel indanone head group coupled to di and tripeptides are described. These compounds are the first proteasome inhibitors have demonstrated high...