(Aminooxy)acetamide-Val-Cit-PAB-MMAE

Names

[ Name ]:
(Aminooxy)acetamide-Val-Cit-PAB-MMAE

Biological Activity

[Description]:

(Aminooxy)acetamide-Val-Cit-PAB-MMAE (MMAE 5) is an intermediate used in the synthetic preparation of drug-linker conjugates for ADC. (Aminooxy)acetamide-Val-Cit-PAB-MMAE is conjugated to polyamide via oxime bond formation to form MMAE polyamide conjugate. Then MMAE polyamide conjugate can be conjugated to Trastuzumab, to make ADC[1].

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. Ouberai Myriam, et al. Preparation of antibody-drug conjugates using polymers and crosslinkers. World Intellectual Property Organization, WO2020128488 A1. 2020-06-25.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆₀H₉₇N₁₁O₁₄

[ Molecular Weight ]:
1196.48

Related Compounds

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