(2Z)-(2H2)-2-Butenedioic acid

Names

[ CAS No. ]:
24461-33-4

[ Name ]:
(2Z)-(2H2)-2-Butenedioic acid

[Synonym ]:
Butylxanthogenic acid thioanhydride
bis-butoxythiocarbonyl-sulfane
CARBONIC ACID,DITHIO-,ANHYDROSULFIDE,O,O-DIBUTYL ESTER
O,O-di-butyltrithiodicarbonate
2-Butenedioic-2,3-d acid, (2Z)-
Xanthic acid,butyl-,anhydrosulfide ester
O,O'-Dideuterio-maleinsaeure
Thioanhydrid der Butylxanthogensaeure
Bis-butoxythiocarbonyl-sulfan
O,O'-dideuterio-maleic acid
(2Z)-(H)-2-Butenedioic acid
(2Z)-(H)But-2-enedioic acid

Biological Activity

[Description]:

Maleic Acid-d2 is the deuterium labeled Maleic Acid[1]. Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes[2][3].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Fonda ML, et al. Glutamate decarboxylase. Substrate specificity and inhibition by carboxylic acids. Biochemistry. 1972 Mar 28;11(7):1304-9.  

[3]. Paudyal R, et al. A novel approach in acidic disinfection through inhibition of acid resistance mechanisms Maleic acid-mediated inhibition of glutamate decarboxylase activity enhances acid sensitivity of Listeria monocytogenes. Food Microbiol. 2018 Feb69:96-104.  

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
355.5±25.0 °C at 760 mmHg

[ Melting Point ]:
137-140ºC(lit.)

[ Molecular Formula ]:
C4H2D2O4

[ Molecular Weight ]:
118.085

[ Flash Point ]:
183.0±19.7 °C

[ Exact Mass ]:
118.023514

[ PSA ]:
74.60000

[ LogP ]:
-0.01

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.526

Safety Information

[ Hazard Codes ]:
Xn

Related Compounds