ALDH1A1-IN-3

Names

[ CAS No. ]:
2439177-97-4

[ Name ]:
ALDH1A1-IN-3

Biological Activity

[Description]:

ALDH1A1-IN-3 (compound 57) is an excellent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor with an IC50 value of 0.379 μM. ALDH1A1-IN-3 can effectively improve glucose consumption in HepG2 cells. ALDH1A1-IN-3 can be used for researching glucose metabolism improvement[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Aldehyde Dehydrogenase (ALDH)
Research Areas >> Metabolic Disease

[Target]

IC50: 0.379 μM (ALDH1A1)[1]


[References]

[1]. Ma Z, et al. Design, synthesis of 1,3-dimethylpyrimidine-2,4-diones as potent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with glucose consumption improving activity. Bioorg Chem. 2020 Aug;101:103971.

Chemical & Physical Properties

[ Molecular Formula ]:
C31H36F3N5O4

[ Molecular Weight ]:
599.64

Related Compounds