Glyphosine
Names
[ CAS No. ]:
2439-99-8
[ Name ]:
Glyphosine
[Synonym ]:
Glycine-N,N-bis(methylenephosphonic Acid)
N,N-di(phosphonomethyl) iminoacetic acid
N,N-bis(phosphonomethyl)aminoacetic acid
<<(carboxymethyl)imino>dimethylene>bisphosphonic acid
EINECS 219-468-4
Glyphosine [ANSI]
2-[bis(phosphonomethyl)amino]acetic acid
Glycine,N,N-bis(phosphonomethyl)
Glycine, N,N-bis(phosphonomethyl)-
N,N-bis-(phosphonomethyl)-glycine
Polaris
Glyphosphine
bis-phosphonomethyl glycine
MFCD00056670
2-(Bis(phosphonomethyl)amino)acetic acid
N,N-Bis(phosphonomethyl)glycine
nitriloacetatodimethylenephosphonic acid
N-Carboxymethyl-N,N-bis(methylenephosphonic Acid)amine
Caswell No. 471A
Glyphosine
Chemical & Physical Properties
[ Density]:
2.0±0.1 g/cm3
[ Boiling Point ]:
668.4±65.0 °C at 760 mmHg
[ Melting Point ]:
263°C
[ Molecular Formula ]:
C4H11NO8P2
[ Molecular Weight ]:
263.080
[ Flash Point ]:
358.0±34.3 °C
[ Exact Mass ]:
262.996002
[ PSA ]:
175.22000
[ LogP ]:
-2.89
[ Vapour Pressure ]:
0.0±4.4 mmHg at 25°C
[ Index of Refraction ]:
1.594
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- MB9120000
- CHEMICAL NAME :
- Glycine, N,N-bis(phosphonomethyl)-
- CAS REGISTRY NUMBER :
- 2439-99-8
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C4-H11-N-O8-P2
- MOLECULAR WEIGHT :
- 263.10
- WISWESSER LINE NOTATION :
- QPQO&1N1VQ1PQQO
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3925 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85ARAE "Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revision Volume(issue)/page/year: 3,60,1976/1977 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1920 mg/kg/24D-C
- TOXIC EFFECTS :
- Liver - changes in liver weight Endocrine - changes in thymus weight Immunological Including Allergic - decrease in humoral immune response
- REFERENCE :
- TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 30,103,1984
Safety Information
[ Symbol ]:
GHS05
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H318
[ Precautionary Statements ]:
P280-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi:Irritant;
[ Risk Phrases ]:
R41
[ Safety Phrases ]:
S26-S2
[ RIDADR ]:
UN 3261 8/PG 3
[ WGK Germany ]:
1
[ RTECS ]:
MB9120000
[ Packaging Group ]:
III
[ Hazard Class ]:
8.0
[ HS Code ]:
2931900042
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2931900042
[ Summary ]:
2931900042 2-(bis(phosphonomethyl)amino)acetic acid。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%
Articles
J. Immunol. 11th ed., 187 , 5921-5930, (2011)
Class II major histocompatibility molecules are the primary susceptibility locus for many autoimmune disorders, including type 1 diabetes. Human DQ8 and I-A(g7), in the NOD mouse model of spontaneous ...
Binding of phosphonate chelating agents and pyrophosphate to apotransferrin.Biochemistry 30(28) , 6930-6, (1991)
Difference ultraviolet spectroscopy has been used to monitor the binding of a series of phosphonate ligands to human apotransferrin. The ligands consist of pyrophosphate as well as the phosphonic acid...
Synthesis, characterization, and in vitro antitumor activity of osteotropic diam(m)ineplatinum(II) complexes bearing a N,N-bis(phosphonomethyl)glycine ligand.J. Med. Chem. 46(23) , 4946-51, (2003)
A series of osteotropic (bone-seeking) [(bis(phosphonomethyl)amino-kappaN)acetato-kappaO(2-)]platinum(II) complexes attached to diammine, ethane-1,2-diamine, cis-R,S-cyclohexane-1,2-diamine, trans-S,S...