InhA-IN-2

Names

[ Name ]:
InhA-IN-2

Biological Activity

[Description]:

InhA-IN-2 (Compound 23) is a Mycobacterium tuberculosis InhA (an enoyl ACP-reductase) inhibitor with an IC50 of 0.31 μM[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

IC50: 0.31 μM (InhA)[1]

[In Vitro]

InhA-IN-2 (Compound 23) (200 µM, 48h) inhibits mycolic acid synthesis (33% growth inhibition) in M. tuberculosis H37Ra[1].

[References]

[1]. Sabbah M, et al. Fragment-Based Design of Mycobacterium tuberculosis InhA Inhibitors. J Med Chem. 2020 May 14;63(9):4749-4761.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₅ClN₂O₂S₂

[ Molecular Weight ]:
366.89

Related Compounds

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