FGFR1 inhibitor-10

Names

[ CAS No. ]:
2426769-76-6

[ Name ]:
FGFR1 inhibitor-10

Biological Activity

[Description]:

FGFR1 inhibitor-10 (Compound 4i) is an FGFR1 inhibitor (IC50: 28 nM). FGFR1 inhibitor-10 inhibits the phosphorylation of FGFR1. FGFR1 inhibitor-10 has anti-angiogenic, anti-invasion activity, and anti-tumor effect[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR

[Target]

FGFR1


[References]

[1]. Li YL, et al. Design, synthesis and evaluation of novel pyrimidinylaminothiophene derivatives as FGFR1 inhibitors against human glioblastoma multiforme. Eur J Med Chem. 2023 Nov 15;260:115764.  

Chemical & Physical Properties

[ Molecular Formula ]:
C26H30F3N7O2S

[ Molecular Weight ]:
561.62

Related Compounds

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