JH-XIV-68-3

Names

[ Name ]:
JH-XIV-68-3

Biological Activity

[Description]:

JH-XIV-68-3 is a selective macrocyclic inhibitor of DYRK1A/B. JH-XIV-68-3 displays selectivity for DYRK1A and close family member DYRK1B in biochemical and cellular assays. JH-XIV-68-3 demonstrates antitumor efficacy in head and neck squamous cell carcinoma (HNSCC) cell lines[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> DYRK

[References]

[1]. Powell CE, et al. Selective Macrocyclic Inhibitors of DYRK1A/B. ACS Med Chem Lett. 2022;13(4):577-585.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₁₇F₃N₈O

[ Molecular Weight ]:
454.41

JH-XIV-68-3

Names

Biological Activity

Chemical & Physical Properties

Related Compounds