Icosanedioic acid

Names

[ Name ]:
Icosanedioic acid

[Synonym ]:
eicosadioic acid
Icosanedioic acid
1,18-Octadecanedicarboxylic acid
eicosa-1,20-dioic acid
eicosane diacid
1,20-icosanedioic acid
Eicossandioic acid
eicosandioic acid
Eicosanedioic acid
MFCD00059627
octadecane-1,18-dicarboxylic acid

Biological Activity

[Description]:

Eicosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Eicosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Non-cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
504.1±23.0 °C at 760 mmHg

[ Melting Point ]:
127ºC

[ Molecular Formula ]:
C₂₀H₃₈O₄

[ Molecular Weight ]:
342.513

[ Flash Point ]:
272.8±19.1 °C

[ Exact Mass ]:
342.277008

[ PSA ]:
74.60000

[ LogP ]:
7.18

[ Appearance of Characters ]:
Powder

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.474

[ Water Solubility ]:
Slightly soluble in water.

MSDS

Click to get detail MSDS

Safety Information

[ Safety Phrases ]:
S22-S24/25

[ HS Code ]:
2917190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2917190090

[ Summary ]:
2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%