epiyangambin

Names

[ Name ]:
epiyangambin

[Synonym ]:
syringaresinol dimethyl ether
lirioresinol B dimethyl ether
epiyangambin

Biological Activity

[Description]:

Epiyangambin is a competitive platelet activating factor receptor (PAF) antagonist that dose-dependently inhibits PAF-induced platelet aggregation. Epiyangambin also inhibits the growth of human colon cancer cells (SW480 cells)[1][2].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

[In Vitro]

Epiyangambin (0-25 µM; 24 h) 以剂量依赖性方式抑制 SW480 细胞的生长[1]。 Cell Viability Assay[1] Cell Line: SW480 cells Concentration: 0-25 µM Incubation Time: 24 h Result: Caused reductions in cell number in a dose-dependent manner.

[In Vivo]

Epiyangambin (20 mg/kg) 显著抑制血小板激活因子受体 (PAF) 诱导的大鼠血小板减少症[2]。

[References]

[1]. Hausott B, et al. Naturally occurring lignans efficiently induce apoptosis in colorectal tumor cells. J Cancer Res Clin Oncol. 2003 Oct;129(10):569-76.

[2]. Castro-Faria-Neto HC, et al. Pharmacological profile of epiyangambin: a furofuran lignan with PAF antagonist activity. J Lipid Mediat. 1993 May;7(1):1-9.

Chemical & Physical Properties

[ Density]:
1.183g/cm3

[ Boiling Point ]:
556.1ºC at 760 mmHg

[ Melting Point ]:
112-114℃

[ Molecular Formula ]:
C₂₄H₃₀O₈

[ Molecular Weight ]:
446.49

[ Flash Point ]:
221.1ºC

[ Exact Mass ]:
446.19400

[ PSA ]:
73.84000

[ LogP ]:
3.81340

[ Vapour Pressure ]:
7.78E-12mmHg at 25°C

[ Index of Refraction ]:
1.537

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2932999099

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%