FFA1 agonist-1

Names

[ CAS No. ]:
2417231-16-2

[ Name ]:
FFA1 agonist-1

Biological Activity

[Description]:

FFA1 agonist-1 (Compound 17a) is an orally active fatty acid receptor 1 (FFA1) agonist with an EC50 of 0.75 μM. FFA1 agonist-1 can be used for type 2 diabetes mellitus research[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> GPR40
Research Areas >> Metabolic Disease

[Target]

EC50: 0.75 μM (FFA1)[1]


[In Vivo]

FFA1 agonist-1 (Compound 17a) (0-25 mg/kg; p.o.) reduces the plasma glucose levels in a dose-dependent manner in mice[1].

[References]

[1]. Kuranov SO, et al. Exploring bulky natural and natural-like periphery in the design of p-(benzyloxy)phenylpropionic acid agonists of free fatty acid receptor 1 (GPR40). Bioorg Chem. 2020 Jun;99:103830.

Chemical & Physical Properties

[ Molecular Formula ]:
C27H36ClNO3

[ Molecular Weight ]:
458.03

Related Compounds