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RET-IN-3

Names

[ CAS No. ]:
2414374-53-9

[ Name ]:
RET-IN-3

Biological Activity

[Description]:

RET-IN-3 (compound 34) is a selective RETV804M kinase inhibitor, with an IC50 of 19 nM[1].

[Related Catalog]:

Research Areas >> Cancer

[Target]

IC50: 19 nM (RETV804M)[1].


[In Vitro]

RET-IN-3 exhibits 16 and 410 fold selectivity compared to wt-RET and KDR, respectively[1].

[References]

[1]. Rebecca Newton, et al. Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RET V804M Kinase. ACS Med Chem Lett. 2020 Feb 28;11(4):497-505.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H21N5O2

[ Molecular Weight ]:
339.39

Safety Information

[ Hazard Codes ]:
Xn

Related Compounds