RET-IN-23c
Names
[ CAS No. ]:
2095172-11-3
[ Name ]:
RET-IN-23c
Biological Activity
[Description]:
RET-IN-23c is a potent and selective RET kinase inhibitor with IC50 of 61.2 nM, shows no significant inhibitory effect against VEGFR-2 and KDR; inhibits the phosphorylation of RET and the phosphorylation of STAT3 and AKT; exhibits antiproliferative effects against BaF3/CCDC6-RET cells with IC50 of 433 nM.
[References]
References 1. Wang C, et al. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2544-2548. View Related Products by Target RET Tyrosine Kinase (c-RET)
Chemical & Physical Properties
[ Molecular Formula ]:
C13H16N6O2
[ Molecular Weight ]:
288.311