HER2-IN-13

Names

[ Name ]:
HER2-IN-13

Biological Activity

[Description]:

HER2-IN-13 (Compound 33) is an HER2 inhibitor with an IC50 of 8 nM. HER2-IN-13 also inhibits wt-EGFR with an IC50 of 0.40 μM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> EGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[Target]

HER2:8 nM (IC50)

EGFR (WT):0.40 μM (IC50)

hERG:13.3 μM (IC50)

[In Vitro]

HER2-IN-13 (Compound 33) 抑制 hERG 通道，IC50 为 13.3 μM[1]。

[References]

[1]. Ding Zhou, et al. Quinazoline derivatives as antitumor agents. Patent WO2020057511A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₂₃ClF₂N₈O₃

[ Molecular Weight ]:
568.96

Related Compounds

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