Steroid sulfatase-IN-2

Steroid sulfatase -IN-2 is an active steroid sulfatase (STS) inhibitor with an IC50 value of 109.5 nM. Steroid sulfatase-IN-2 can be used for the research of hormone-dependent cancers, such as estrogen-dependent breast and endometrial cancer[1].

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

IC50：109.5 nM (STS)[1]

Steroid sulfatase-IN-2 (compound 1h, 0.001-10 μM, 1 h) inhibits STS in the lysate of JEG-3 cells, with an IC50 value of 109.5 nM[1]. Steroid sulfatase-IN-2 (1-1 μM, 20 h) inhibits STS in a whole-cell assay against JEG-3 cells, with an IC50 value of 13.6 nM[1]. Steroid sulfatase-IN-2 (0.01-100 μM, 5 days) shows dose-dependent antiproliferative activity against T-47D estrogen-dependent breast cancer cells[1]. Cell Viability Assay[1] Cell Line: T-47D cells Concentration: 0.01-100 μM Incubation Time: 5 days Result: Inhibited cell proliferation with an IC50 value of 5.78 μM.

[1]. Mohammed I El-Gamal, et al. A new series of aryl sulfamate derivatives: Design, synthesis, and biological evaluation. Bioorg Med Chem. 2020 Apr 15;28(8):115406.