Antibacterial agent 102

Names

[ Name ]:
Antibacterial agent 102

Biological Activity

[Description]:

Antibacterial agent 102 (compound 32) possesses potent in vitro and in vivo antibacterial activity, with MICs < 0.5 μg/mL in Staphylococcus aureus (S. aureus). Antibacterial agent 102 also moderately inhibits CYP3A4 with an IC50 value of 6.148 μM. Antibacterial agent 102 can reduce Methicillin-resistant Staphylococcus aureus (MRSA) load in thigh infected mice[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

MIC: < 0.5 μg/mL (S. aureus)[1] IC50: 6.148 μM (CYP3A4)[1]

[References]

[1]. Zhang Z, et al. Design, synthesis and biological activities of novel pleuromutilin derivatives with a substituted triazole moiety as potent antibacterial agents. Eur J Med Chem. 2020;204:112604.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₅H₄₉N₅O₅S

[ Molecular Weight ]:
651.86

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.