Antimicrobial agent-2

Antimicrobial agent-2 (compound V-a) is a broad-spectrum antimicrobial agent, possessing inhibitory activity against various Gram-positive and -negative bacteria. Antimicrobial agent-2 has excellent inhibitory effect on Methicillin-resistant Staphylococcus aureus (MRSA) with a MIC of 1 μg/mL. Antimicrobial agent-2 can effectively damage the membrane and lead to the leakage of protein, also can induce the generation of ROS. Antimicrobial agent-2 exhibits low toxicity, no obvious resistance and good bioavailability[1].

Research Areas >> Infection

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS

MIC: 1 μg/mL (MRSA), 2 μg/mL (Enterococcus faecalis)[1]

[1]. Yang XC, et al. Coumarin thiazoles as unique structural skeleton of potential antimicrobial agents. Bioorg Chem. 2022;124:105855.