TRV120055

Names

[ Name ]:
TRV120055

Biological Activity

[Description]:

TRV120055 is a Gq-biased agonists, exhibits 10-fold larger molecular efficacies at the AT1R-Gq fusion protein compared with the AT1R-βarr2 fusion protein[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Rajagopal S, et, al. Quantifying ligand bias at seven-transmembrane receptors. Mol Pharmacol. 2011 Sep;80(3):367-77.

[2]. Strachan RT, et, al. Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR). J Biol Chem. 2014 May 16; 289(20): 14211-24.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₄H₅₄N₁₂O₇

[ Molecular Weight ]:
742.87

Related Compounds

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