Anticancer agent 127

Names

[ CAS No. ]:
2410953-19-2

[ Name ]:
Anticancer agent 127

Biological Activity

[Description]:

Anticancer agent 127 (142D6) is an IAP inhibitor that covalently targets the BIR3 domains of XIAP, cIAP1, and cIAP2. Anticancer agent 127 targets the BIR3 domains of XIAP, cIAP1, and cIAP2 with IC50s of 12 nM, 14 nM, and 9 nM, respectively. Anticancer agent 127 has anticancer effects[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Apoptosis >> IAP

[Target]

IC50: 12 nM (XIAP-BIR3), 14 nM (cIAP1-BIR3), and 9 nM (cIAP2-BIR3)[1]


[References]

[1]. Udompholkul P, et al. Characterization of a Potent and Orally Bioavailable Lys-Covalent Inhibitor of Apoptosis Protein (IAP) Antagonist. J Med Chem. 2023 Jun 22;66(12):8159-8169.  

Chemical & Physical Properties

[ Molecular Formula ]:
C26H37FN4O6S

[ Molecular Weight ]:
552.66