2410953-19-2

2410953-19-2 structure

Name: Anticancer agent 127
Chemical Name: Anticancer agent 127
CAS Number: 2410953-19-2
Molecular Formula: C₂₆H₃₇FN₄O₆S
Molecular Weight: 552.66
Catalog: Signaling Pathways Apoptosis IAP
Create Date: 2023-09-20 04:39:41
Modify Date: 2024-01-19 18:14:01
Anticancer agent 127 (142D6) is an IAP inhibitor that covalently targets the BIR3 domains of XIAP, cIAP1, and cIAP2. Anticancer agent 127 targets the BIR3 domains of XIAP, cIAP1, and cIAP2 with IC50s of 12 nM, 14 nM, and 9 nM, respectively. Anticancer agent 127 has anticancer effects[1].

Name	Anticancer agent 127

Description	Anticancer agent 127 (142D6) is an IAP inhibitor that covalently targets the BIR3 domains of XIAP, cIAP1, and cIAP2. Anticancer agent 127 targets the BIR3 domains of XIAP, cIAP1, and cIAP2 with IC50s of 12 nM, 14 nM, and 9 nM, respectively. Anticancer agent 127 has anticancer effects[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> IAP
Target	IC50: 12 nM (XIAP-BIR3), 14 nM (cIAP1-BIR3), and 9 nM (cIAP2-BIR3)[1]
References	[1]. Udompholkul P, et al. Characterization of a Potent and Orally Bioavailable Lys-Covalent Inhibitor of Apoptosis Protein (IAP) Antagonist. J Med Chem. 2023 Jun 22;66(12):8159-8169.

Molecular Formula	C₂₆H₃₇FN₄O₆S
Molecular Weight	552.66