FGFR1 inhibitor-2

Names

[ Name ]:
FGFR1 inhibitor-2

Biological Activity

[Description]:

FGFR1 inhibitor-2 is a FGFR1 inhibitor (IC50 is 4.55 μM in MDA-MB-231 cells). FGFR1 inhibitor-2 can be used for the research of metastatic triple-negative breast cancer[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR

[Target]

FGFR1

[In Vitro]

FGFR1 inhibitor-2 (3 and 6 μM; 48 hours; MDA-MB-231) reduces the expression of FGFR1[1]. FGFR1 inhibitor-2 (0~5 μM; MDA-MB-231) increases the apoptotic index by 10.6-fold at 5 μM[1]. Western Blot Analysis[1] Cell Line: MDA-MB-231 Concentration: 3 and 6 μM Incubation Time: 48 hours Result: Reduced the expression of FGFR1.

[References]

[1]. Ashraf-Uz-Zaman M, et al. Design, synthesis and structure-activity relationship study of novel urea compounds as FGFR1 inhibitors to treat metastatic triple-negative breast cancer. Eur J Med Chem. 2021;209:112866.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₂F₅N₃O₃

[ Molecular Weight ]:
507.45

FGFR1 inhibitor-2

Names

Biological Activity

Chemical & Physical Properties

Related Compounds