Antibacterial agent 98

Names

[ Name ]:
Antibacterial agent 98

Biological Activity

[Description]:

Antibacterial agent 98 (compound g37) is a potent and orally active antibacterial agent. Antibacterial agent 98 inhibits the ATPase activity of Gyrase B and impairs Staphylococcus aureus (S. aureus ) DNA supercoiling. Antibacterial agent 98 shows antibacterial activity and not induce resistance development of MRSA (methicillin-resistant S. aureus)[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Antibacterial agent 98 (compound g37) shows antibacterial activity with an NICs of 0.1 μg/mL for S. aureus ATCC29213 and an IC50 of 0.15 µM for GyrB[1]. Antibacterial agent 98 shows cytotoxicity with IC50s of 55.3, 38.8 µM for HepG2, HUVEC cells, respectively[1].

[References]

[1]. Xue W, et al. N-thiadiazole-4-hydroxy-2-quinolone-3-carboxamides bearing heteroaromatic rings as novel antibacterial agents: Design, synthesis, biological evaluation and target identification. Eur J Med Chem. 2020 Feb 15;188:112022.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₃N₅O₃S₂

[ Molecular Weight ]:
399.45

Related Compounds

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