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P-gp inhibitor 2

Names

[ CAS No. ]:
2408406-89-1

[ Name ]:
P-gp inhibitor 2

Biological Activity

[Description]:

P-gp inhibitor 2 is a potent P-gp inhibitor. P-gp inhibitor 2 shows reverse Doxorubicin resistance (IC50=0.22 µM) in P-gp overexpressing human colorectal carcinoma cells (SW600 Ad300)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein

[In Vitro]

P-gp inhibitor 2 (compound 2) exhibits no cytotoxicity (IC50>30 µM) toward human carcinoma (SW600) cells[1].

[References]

[1]. Dewa AA, et al. Neochrysosporazines: Precursor-Directed Biosynthesis Defines a Marine-Derived Fungal Natural Product P-Glycoprotein Inhibitory Pharmacophore. J Med Chem. 2022, 65(3):2610-2622.

Chemical & Physical Properties

[ Molecular Formula ]:
C29H26N2O6

[ Molecular Weight ]:
498.53

Related Compounds