EP3 antagonist 4

Names

[ Name ]:
EP3 antagonist 4

Biological Activity

[Description]:

EP3 antagonist 4 (Compound 28) is an EP3 antagonist, with a Ki value of 2 nM for hEP. EP3 antagonist 4 shows low in vivo clearance, high oral AUC, and good bioavailability in the rat full PK studies. EP3 antagonist 4 can be used for research of beta cell dysfunction in diabetes[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor

Research Areas >> Metabolic Disease

[References]

[1]. Zhu B, et al. Discovery and Optimization of 7-Alkylidenyltetrahydroindazole-Based Acylsulfonamide EP3 Antagonists. ACS Med Chem Lett. 2021 Dec 7;13(1):111-117.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₀Cl₃FN₄O₃S₂

[ Molecular Weight ]:
577.91

Related Compounds

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