2408297-80-1

2408297-80-1 structure

Name: EP3 antagonist 4
Chemical Name: EP3 antagonist 4
CAS Number: 2408297-80-1
Molecular Formula: C₂₂H₂₀Cl₃FN₄O₃S₂
Molecular Weight: 577.91
Catalog: Signaling Pathways GPCR/G Protein Prostaglandin Receptor
Create Date: 2023-09-28 22:57:36
Modify Date: 2024-01-02 17:49:39
EP3 antagonist 4 (Compound 28) is an EP3 antagonist, with a Ki value of 2 nM for hEP. EP3 antagonist 4 shows low in vivo clearance, high oral AUC, and good bioavailability in the rat full PK studies. EP3 antagonist 4 can be used for research of beta cell dysfunction in diabetes[1].

Name	EP3 antagonist 4

Description	EP3 antagonist 4 (Compound 28) is an EP3 antagonist, with a Ki value of 2 nM for hEP. EP3 antagonist 4 shows low in vivo clearance, high oral AUC, and good bioavailability in the rat full PK studies. EP3 antagonist 4 can be used for research of beta cell dysfunction in diabetes[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Research Areas >> Metabolic Disease
References	[1]. Zhu B, et al. Discovery and Optimization of 7-Alkylidenyltetrahydroindazole-Based Acylsulfonamide EP3 Antagonists. ACS Med Chem Lett. 2021 Dec 7;13(1):111-117.

Molecular Formula	C₂₂H₂₀Cl₃FN₄O₃S₂
Molecular Weight	577.91