Microcolin H

Names

[ CAS No. ]:
2408008-21-7

[ Name ]:
Microcolin H

Biological Activity

[Description]:

Microcolin H is a marine lipopeptide and phosphatidylinositol transfer protein ligand that targets PITPα/β. Microcolin H increases the conversion of LC3I to LC3II and reduces p62 levels in cancer cells, leading to autophagy cell death (Autophagy). Microcolin H effectively inhibits tumor development and has anti-proliferative activity in nude mouse subcutaneous tumor models[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others
Signaling Pathways >> Autophagy >> Autophagy

[Target]

Phosphatidylinositol transfer protein, PITPα/β[1]


[References]

[1]. Yang H et al. Microcolin H, a novel autophagy inducer, exerts potent antitumour activity by targeting PITPα/β. Signal Transduct Target Ther. 2023 Nov 15;8(1):428.  

Chemical & Physical Properties

[ Molecular Formula ]:
C38H63N5O9

[ Molecular Weight ]:
733.93

Related Compounds

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