Topoisomerase II inhibitor 16

Names

[ Name ]:
Topoisomerase II inhibitor 16

Biological Activity

[Description]:

Topoisomerase II inhibitor 16 (compound CT3) is a selective, orally active, brain-penetrant and irreversible trypanosomal topoisomerase II inhibitor by stabilizing double-stranded DNA:enzyme cleavage complexes. Topoisomerase II inhibitor 16 has the potential for Chagas disease research[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

Research Areas >> Infection

[References]

[1]. Srinivasa P S Rao, et al. Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections. Science. 2023 Jun 30;380(6652):1349-1356.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₂F₄N₆O

[ Molecular Weight ]:
416.33

Related Compounds

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