PI3KC2α-IN-2

Names

[ Name ]:
PI3KC2α-IN-2

Biological Activity

[Description]:

PI3KC2α-IN-2 is a potent and selective PI3KC2α inhibitor (IC50: 121 nM). PI3KC2α-IN-2 interacts with the ATP-binding site of PI3KC2α.. PI3KC2α-IN-2 can be used in the research of thrombosis, diabetes and cancers[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Cardiovascular Disease

Signaling Pathways >> PI3K/Akt/mTOR >> PI3K

Research Areas >> Metabolic Disease

[Target]

PI3KC2α:121 nM (IC50)

PI3KC2β:1399 nM (IC50)

PI3KC2γ:>10 μM (IC50)

[In Vitro]

PI3KC2α-IN-2 (PITCOIN2) is selective against PI3KC2γ but showed micromolar activity on PI3KC2β[1].

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₀N₆O₃S₂

[ Molecular Weight ]:
516.59

Related Compounds

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