Deferitrin

Names

[ Name ]:
Deferitrin

[Synonym ]:
(4S)-2-(2,4-Dihydroxyphenyl)-4-methyl-4,5-dihydro-1,3-thiazole-4-carboxylic acid
4'-Hydroxydesazadesferrithiocin
GT 56-252
4-Thiazolecarboxylic acid, 2-(2,4-dihydroxyphenyl)-4,5-dihydro-4-methyl-, (4S)-
UNII-T69Y9LDN44
Deferitrin

Biological Activity

[Description]:

Deferitrin (GT-56-252), a desferrithiocin (DFT) analogue, is an orally active trident iron chelator. Deferitrin is used for chronic iron overload due to transfusional therapy. Deferitrin has the potential for beta-thalassemia major[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[In Vitro]

The iron-clearing efficiency (ICE) of Deferitrin (GT-56-252) in a non-iron-overloaded rodent model after oral (po) administration at 300 µmol/kg is shown to be 1.1%[1].

[References]

[1]. Raymond J Bergeron, et al. Design, Synthesis, and Testing of Non-Nephrotoxic Desazadesferrithiocin Polyether Analogues. J Med Chem. 2008 Jul 10;51(13):3913-23.

[2]. Joanne M Donovan, et al. Preclinical and Clinical Development of Deferitrin, a Novel, Orally Available Iron Chelator. Ann N Y Acad Sci. 2005;1054:492-4.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
525.8±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₁H₁₁NO₄S

[ Molecular Weight ]:
253.274

[ Flash Point ]:
271.8±32.9 °C

[ Exact Mass ]:
253.040878

[ PSA ]:
115.42000

[ LogP ]:
-0.13

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.683

Synthetic Route

Click to get detail synthetic route

Related Compounds

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